Abstract

A decade of research on DNA sequencing-by-hybridization (SBH) has produced the consensus that its ultimate success is predicated on the adoption of gapped probing patterns. Gapped patterns call for the deployment of wild-card universal bases. Unfortunately, ideal universal bases remain an elusive goal to-date. While the synthesis of such components is being pursued, efficiency can be gained by abandoning the traditional purely combinatorial model and adopting a novel approach, called "analog spectrum", that tightly couples the biochemical and combinatorial steps of the technology.

Bio: A biographical sketch of Prof. Preparata can be found here.